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As you prepare your abstract for the 2018 AMP Annual Meeting Expo, consider that our theme this year is, " Precision Medicine Starts Here. " Your exciting new work presented in abstract form will round out our relevant and comprehensive program. The Program Committee recognizes that abstracts contain cutting-edge work in our rapidly evolving field. The work you present will lead to new methods and diagnostic markers to achieve outstanding patient care. Some of the most enthusiastic discussion and productive collaborations begin at the poster sessions and continue throughout the meeting and beyond. We look forward to your submissions and to seeing you in November in San Antonio!

Precision Medicine Starts Here.
On behalf of the 2018 AMP Program Committee ,
Lynne V. Abruzzo, MD, PhD (Chair)

The abstract submission portal is now closed.

All participants at the AMP 2018Annual Meeting Expo are invited to submit abstracts of original studies related to molecular pathology and diagnostics.

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Author Information
Eligibility

Only AMP Regular Members are eligible to submit abstracts. Associate Members (Trainees) and non-members must have a Regular Member sponsor their abstract. The Regular Member does not need to be an author on the abstract. If you are not a Regular Member of AMP, Reebok Womens All Terrain Thunder 20 Running Shoe Neon Blue/Handy Blue/Instinct Blue/Solar Yellow outlet new arrival BEvTP
to submit your abstract today. You may submit an abstract and apply to join AMP on the same day, up to and through the submission deadline. However, we encourage you to join AMP in advance of the deadline!

Submission Categories

*Abstract submissions in the "Other (e.g. Education)" topic category may include descriptions of novel educational approaches, innovative programs, pioneering technologies, etc. As with other abstract submissions, these abstract submissions must demonstrate the scientific method, i.e., describe the methodology and data collection, identify how to measure, analyze, and report outcomes, and provide conclusions. All submitted abstracts will be reviewed with the same criteria (see below).

Deadlines

Submission: May 31, 2018 at11:59 pm ET. NO EXCEPTIONS . The final abstract submission step is not complete until you have clicked the "Save and Finalize" button. The Corresponding Author will receive a confirmation email, but only after the abstract has been successfully finalized and submitted. Abstracts that are in process but not finalized after the deadline will not be considered for acceptance and/or awards.

Fig. 1
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Organization of ST-segment elevation myocardial infarction patient pathway describing pre- and in-hospital management and reperfusion strategies within 12 h of first medical contact.

Fig. 1
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Organization of ST-segment elevation myocardial infarction patient pathway describing pre- and in-hospital management and reperfusion strategies within 12 h of first medical contact.

Despite its frequent contraindications, limited effectiveness in inducing reperfusion, and greater bleeding risk, fibrinolytic therapy, preferably administered as a pre-hospital treatment [ 81 ], remains an important alternative to mechanical revascularization. In Europe, 5–85% of patients with STEMI undergo primary PCI, a wide range that reflects the variability or allocation of local resources and capabilities [ 82 ]. Even with an optimal network organization, transfer delays may be unacceptably long before primary PCI is performed, especially in patients living in mountain or rural areas or presenting to non-PCI centres. The incremental benefit of primary PCI, over timely fibrinolysis, is jeopardized when PCI-related delay exceeds 60–120 min, depending on age, duration of symptoms, and infarct location [ 83 , 84 ].

Facilitated PCI, or pharmaco-mechanical reperfusion, is defined as elective use of reduced or normal-dose fibrinolysis combined with glycoprotein IIb-IIIa (GPIIb-IIIa) inhibitors or other antiplatelet agents. In patients undergoing PCI 90–120 min after FMC, facilitated PCI has shown no significant advantages over primary PCI. The use of tenecteplase and aspirin as facilitating therapy was shown to be detrimental compared with primary PCI, with increased ischaemic and bleeding events, and a trend towards excess mortality [ 85 ]. The combination of half-dose lytics with GPIIb-IIIa inhibitors showed a non-significant reduction in adverse events at the price of excess bleeding [ 86 ].

Pre-hospital full-dose fibrinolysis has been tested in the CAPTIM trial [ 81 ], using an emergency medical service (EMS) able to perform pre-hospital diagnosis and fibrinolysis, with equivalent outcome to primary PCI at 30 days and 5 years. Following pre-hospital fibrinolysis, the ambulance should transport the patient to a 24 h a day/7 days a week PCI facility.

In cases of persistent ST-segment elevation after fibrinolysis, defined as more than half of the maximal initial elevation in the worst ECG lead, and/or persistent ischaemic chest pain, rapid transfer to a PCI centre for rescue angioplasty should be considered [ 80 , 87 ]. Re-administration of a second dose of fibrinolysis was not shown to be beneficial.

In the case of successful fibrinolysis, patients are referred within 24h for angiography and revascularization as required [ 77–79 ].

Ventricular arrhythmias are associated with acute or chronic CAD. Revascularization of hibernating myocardium may improve electrical stability and reduces the likelihood of ventricular arrhythmias. However, several studies demonstrated that a significant number of patients remained arrhythmia inducible after revascularization resulting in a 13% SCD rate. Patients are candidates for ICD therapy if revascularization cannot be achieved or in the case of prior MI with significant LV dysfunction.

In patients with monomorphic sustained ventricular tachycardia (VT), revascularization may help to lower the number of recurrences but is not considered to be sufficient and ICD implantation is the first line of SCD prevention. However, percutaneous endo- or epicardial catheter ablation procedures are becoming increasingly successful and may be considered in patients with haemodynamically stable VT.

In patients scheduled for cardiac resynchronization therapy (CRT) or CRT combined with ICD therapy, having concomitant cardiac surgery (a revascularization procedure or LV reconstruction/valve repair), epicardial LV lead implantation may be considered. Potential advantages include avoidance of subsequent transvenous LV lead placement and convenient selection of the preferred lead location. When operating on already implanted patients, the ICD should be switched off. In patients having PCI, the ICD should be implanted first to avoid DAPT discontinuation.

Patients admitted for surgical revascularization are usually taking many medicines including β-blockers, ACE inhibitors, statins, and antiplatelet drugs. β-blockers should not be stopped to avoid acute ischaemia upon discontinuation.

Surgical procedures are complex interactions between human and material resources. The best performance is obtained through experience and routine, process control, case-mix, and volume load. The surgical procedure is performed within a hospital structure and by a team specialized in cardiac surgery. The surgical, anaesthesiological, and intensive care procedures are written down in protocols [ 192 ].

The initial development of CABG was made possible with the use of extracorporeal circulation and induced ventricular fibrillation. When aortic cross-clamping is used to perform the distal anastomoses, the myocardium can be protected against ensuing ischaemia by several methods.

CABG is performed using extracorporeal circulation (CPB) in 70% of all operations worldwide. This includes a median sternotomy, ITA(s) dissection, and, when appropriate, simultaneous harvesting of the venous and or radial artery grafts. Endoscopic vein-graft harvesting cannot be recommended at present as it has been associated with vein-graft failure and adverse clinical outcomes. CPB requires profound anticoagulation using heparin for an activated clotting time > 400s.

Partial or total aortic cross-clamping allows the construction of proximal anastomoses. A single cross-clamp may be preferred with the aim of reducing atheroembolic events. Epiaortic ultrasonography, visualizing atherosclerotic plaques, can modify the surgical approach but was not shown to reduce the incidence of cerebral emboli [ 193 ].

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